RIBONUCLEOTIDE REDUCTASES
نویسندگان
چکیده
منابع مشابه
Virus-Encoded Ribonucleotide Reductases
Ribonucleotide reductases [EC 1.17.4.] are a group of enzymes which critically contribute to the biosynthesis of deoxyribonucleotides (dNTPs), the monomeric precursors of DNA polymerization. By a radical reaction mechanism, they catalyze the reduction of the ribonucleotides, ADP, GDP, CDP, and UDP, mostly at the diphosphate level, to their deoxy conterparts dADP, dGDP, dCDP, and dUDP, respectiv...
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Ribonucleotide reductases catalyze in all living organisms the production of the deoxyribonucleotides required for DNA replication and repair. Their appearance during evolution was a prerequisite for the transition from the "RNA world," where RNA sufficed for both catalysis and information transfer, to today's situation where life depends on the interplay among DNA, RNA, and protein. Three clas...
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Ribonucleotide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents.
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Ribonucleotide reductase (RNR) is a key enzyme that mediates the synthesis of deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This enzyme converts ribonucleotides to deoxyribonucleotides, the building blocks for DNA replication, and repair. Clearly, RNR enzymes have contributed to the appearance of genetic material that exists today, being essential for the evo...
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Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to deoxynucleotides in all organisms. The class I RNRs are composed of two subunits, alpha and beta, with proposed quaternary structures of alpha2beta2, alpha6beta2, or alpha6beta6, depending on the organism. The alpha subunits bind the nucleoside diphosphate substrates and the dNTP/ATP allosteric effectors that govern spec...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 1998
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev.biochem.67.1.71